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Research Articles & Media Links

Research Articles

  • Yoni K. Ashar, PhD; Ethan L. Low, BS; Karen Knight, MD; et al. Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: 5-Year Follow-Up of a Randomized Clinical Trial. July 30, 2025 doi: 10.1001/jamapsychiatry.2025.1844. Read Here

  • Ashar YK, Sun M, Knight K, Flood TF, Anderson Z, Kaptchuk TJ, Wager TD. Open-Label Placebo Injection for Chronic Back Pain With Functional Neuroimaging: A Randomized Clinical Trial. JAMA Netw Open. 2024 Sep 3;7(9):e2432427. doi: 10.1001/jamanetworkopen.2024.32427. PMID: 39259542; PMCID: PMC11391328.

  • Auriemma M, Borgstrom H, Itskevich D, Kruse R, Latzka E, Martin J, Moore B, Gruner M, Bodor M, Cianca J, Jayaram P, Knight K, Sussman WI, Townsend C, Borg-Stein J. Curriculum for training in orthobiologics. PM R. 2024 Jul;16(7):769-771. doi: 10.1002/pmrj.13249. Epub 2024 Jul 17. PMID: 39015999.
  • Sussman WI, Auriemma M, Bodor M, Cianca J, Jayaram P, Knight K, Townsend C, Borg-Stein J. Developing and integrating an orthobiologics curriculum. PM R. 2024 Jul;16(7):785-788. doi: 10.1002/pmrj.13252. Epub 2024 Jul 16. PMID: 39011829.
  • Ashar YK, Gordon A, Schubiner H, Uipi C, Knight K, Anderson Z, Carlisle J, Polisky L, Geuter S, Flood TF, Kragel PA, Dimidjian S, Lumley MA, Wager TD. Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: A Randomized Clinical Trial. JAMA Psychiatry. 2022 Jan 1;79(1):13-23. doi: 10.1001/jamapsychiatry.2021.2669. PMID: 34586357; PMCID: PMC8482298.
  • Knight KH, Brand FM, Mchaourab AS, Veneziano G. Implantable intrathecal pumps for chronic pain: highlights and updates. Croat Med J. 2007 Feb;48(1):22-34. PMID: 17309136; PMCID: PMC2080496.

Dr. Knight in the Media

brain activitiy

‘On Pain:’ understanding the connection between physical and mental pain

By Andrea Dukakis | February 28, 2022

Pain is physical. But it’s also mental. And that mind-body connection is the subject today of “On Pain,” our new series about pain management. Greg Whisler had chronic pain for years until he took part in a pain study at CU Boulder, involving a treatment called Pain Reprocessing Therapy. For more on the study, we’re joined by Yoni Ashar, the researcher who conducted it, and by Dr. Karen Knight who is a pain management physician in the Greater Denver area.

two red chairs facing one another

Pain Brain

A documentary about a massive neuroscience study that challenges the medical industry’s approach to chronic pain.

When therapist Alan Gordon suggests psychology as the cure for millions of pain sufferers, it garners the attention of Yoni Ashar, a doctoral student working in the lab of Dr. Tor Wager, who is willing to put Alan’s claims to the test.

PAIN BRAIN balances scientific breakthrough alongside intimate therapy sessions with patients as Alan attempts to cure patients with only words and information.

How successful the treatment is could catalyze a paradigm shift – from body to brain – amongst doctors and patients.

Transform Your Mind, Body, and Brain

Experience Renewed Vitality & Wellness at Somadelic Health

Experience Renewed Vitality & Wellness at Somadelic Health