A New Way to Reset Your Brain Circuits — At Home
Proliv™Rx uses gentle nerve stimulation to help restore the brain-body signals that drive mood, memory, focus, and resilience. No medication. No clinic visits.
Your Brain and Body Are Always Talking
Your brain and body are in a constant, two-way conversation that directly shapes your emotions, thoughts, sleep, and stress levels. When this loop is disrupted—by trauma, depression, injury, or cognitive changes—the effects ripple everywhere. It doesn’t just impact your mood; it manifests physically through:
What Is Proliv™Rx?
Proliv™Rx is an FDA-approved (January 2026) is a wearable device — it looks like a headband — that delivers very gentle electrical pulses to specific nerves on your scalp for 40 minutes, twice a day at home.
What Makes It Different?
How Does It Work?
Proliv™Rx sends gentle signals through face and scalp nerves directly to brain regions regulating mood, stress, and memory. This stimulation reaches a neural hub linking the heart and gut, interrupting unhelpful patterns. It acts like a sensory on-ramp to reshape traffic across the entire network.
Who Can Proliv™Rx Help?
Rather than treating just a diagnostic label, Somadelic Health evaluates the specific brain circuits disrupted in your unique body. Proliv™Rx targets overlapping circuit breakdowns across four key areas:
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Depression (MDD): Stimulates under-firing, low-state mood circuits. The MOOD trial demonstrated meaningful remission rates, even for those resistant to medication.
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PTSD & Trauma: Calms an over-active, high-alert stress response. A clinical trial evaluating PTSD and depression showed a remarkably large effect size ().
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Traumatic Brain Injury (TBI): Restores dopamine and serotonin circuits damaged by physical trauma, addressing the mood and trauma symptoms common after a brain injury.
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Mild Cognitive Impairment (MCI): Supports the neural pathways tied to memory consolidation. Early intervention offers the best opportunity while circuits are still fully intact.
What Does the Research Show?
The MOOD trial was a rigorous, blinded study involving 124 participants with treatment-resistant depression across 13 US and Israeli medical centers. It compared the active device against an identical fake control.
- 21.3% Remission rate at 8 weeks with Proliv™Rx (vs. 6% with sham)
- 31.7% Remission rate at 16 weeks — results kept improving with sustained use
- >90% Adherence rate — people kept using it consistently because it was tolerable
- 0 Participants reported worsening of depression symptoms
Results got better the longer people used the device — which makes sense, because rewiring brain circuits is a gradual process, not an on/off switch.
What Are the Side Effects?
Unlike medication, side effects are mild, localized to the scalp, and free of systemic issues like worsened mood or seizures. The most common effects include:
- Mild tingling or buzzing (often described as pleasant)
- Temporary skin redness or mild irritation under the device
- Occasional mild headaches
- Minor fit discomfort (easily resolved by adjusting the positioning)
Is Proliv™Rx Right for You?
Proliv™Rx is a prescription device — you need a physician to evaluate your history and prescribe it. The FDA approved it specifically for adults with major depressive disorder who haven’t responded well to at least one antidepressant. But at Somadelic Health, we look at the full picture: your brain circuit profile, your history with other treatments, your goals, and which combination of approaches is most likely to produce lasting change for you.
It’s likely worth exploring if you:
Ready to Explore Whether Proliv™Rx Fits Your Care Plan?
The Somadelic Health team will map your full brain-body circuit profile and work with you to build a precision plan that addresses the root causes — not just the symptoms.
Proliv™Rx is FDA-approved as an adjunctive treatment for adults with major depressive disorder who have not adequately responded to at least one antidepressant medication. It is a prescription device. Applications described for PTSD, TBI, and MCI reflect emerging mechanistic and clinical evidence at varying levels; consult the Somadelic Health team to determine appropriateness for your individual situation.
Our Approach to Healing
You’ll receive a thorough evaluation, a clear explanation of your brain health, and a step-by-step plan for care. Our team supports you at every stage, helping you reclaim clarity, calm, and control.
Precision Diagnostics
We use advanced neuro-assessment tools to map your brain’s unique patterns and identify underlying imbalances.
Personalized Plans
Your treatment is tailored to your specific symptoms, history, and goals, ensuring the most effective path to recovery.
Integrative Support
We combine neuroplasticity-based therapies, medication management, and lifestyle guidance for comprehensive healing.